Cancer-fighting properties of hops
"I got interested in xanthohumol back in 1995 when I became a post-doc at Oregon State University with Professor Max Deinzer. We were investigating the chemistry of hops and focused on xanthohumol, which we were able to isolate. Professor Don Buehler, Val Miranda, and I investigated the activity of xanthohumol in cancer cells and found that it induces phase 2 enzymes—enzymes that detoxify carcinogens. That is good for cancer chemoprotection. We also found that xanthohumol inhibits phase 1 enzymes that activate pro-carcinogens. So the effect is two-fold: xanthohumol prevents activation of pro-carcinogens into carcinogens by phase 1 enzymes and helps detoxify carcinogens by the phase 2 process. We can clearly say that xanthohumol is a cancer chemoprotective compound in cell culture," Stevens said.